For research use only. Not for therapeutic Use.
Androgen Receptor Antagonist 1（Cat No.:I015515）is a synthetic small-molecule inhibitor designed to block the activity of the androgen receptor (AR), a nuclear hormone receptor central to the regulation of male reproductive biology and the progression of prostate cancer. By competing with natural androgens for AR binding, it prevents receptor activation, nuclear translocation, and transcription of AR-driven genes. This antagonist is widely used in research to study hormone signaling, castration-resistant prostate cancer (CRPC), and endocrine therapy resistance, providing a valuable probe for therapeutic development and mechanistic investigations.
| CAS Number | 1338812-36-4 |
| Synonyms | N-[3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-1-(2-hydroxyethyl)pyrazole-4-carboxamide |
| Molecular Formula | C21H25ClN4O3 |
| Purity | ≥95% |
| IUPAC Name | N-[3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-1-(2-hydroxyethyl)pyrazole-4-carboxamide |
| InChI | InChI=1S/C21H25ClN4O3/c1-20(2)18(25-17(28)14-11-24-26(12-14)7-8-27)21(3,4)19(20)29-15-6-5-13(10-23)16(22)9-15/h5-6,9,11-12,18-19,27H,7-8H2,1-4H3,(H,25,28) |
| InChIKey | HJJNHDLYWZTKGQ-UHFFFAOYSA-N |
| SMILES | CC1(C(C(C1OC2=CC(=C(C=C2)C#N)Cl)(C)C)NC(=O)C3=CN(N=C3)CCO)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
