For research use only. Not for therapeutic Use.
Anastrozole(CAT: A000973) is a nonsteroidal aromatase inhibitor (C₁₇H₁₉N₅) used primarily in the treatment of hormone receptor-positive breast cancer in postmenopausal women. By selectively inhibiting the aromatase enzyme, it reduces estrogen production, depriving estrogen-dependent cancer cells of the hormone needed for their growth. Anastrozole is administered orally and is known for its high potency, favorable tolerability, and minimal effect on adrenal corticosteroid synthesis. It is also utilized in certain cases of infertility and gynecomastia. In research, anastrozole serves as a valuable tool for studying estrogen-related pathways and endocrine therapies in oncology and reproductive health.
| CAS Number | 120511-73-1 |
| Synonyms | 120511-73-1; Arimidex; Anastrazole; Anastrozol; ZD1033 |
| Molecular Formula | C17H19N5 |
| Purity | ≥95% |
| Target | Cytochrome P450 |
| Solubility | 10 mM in DMSO |
| Storage | -20°C |
| IC50 | 15 nM |
| IUPAC Name | 2-[3-(2-cyanopropan-2-yl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile |
| InChI | InChI=1S/C17H19N5/c1-16(2,9-18)14-5-13(8-22-12-20-11-21-22)6-15(7-14)17(3,4)10-19/h5-7,11-12H,8H2,1-4H3 |
| InChIKey | YBBLVLTVTVSKRW-UHFFFAOYSA-N |
| SMILES | CC(C)(C#N)C1=CC(=CC(=C1)CN2C=NC=N2)C(C)(C)C#N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
