Anabaseine

• CAT Number: R001632
• CAS Number: 3471-05-4
• Molecular Formula: C10H12N2
• Molecular Weight: 160.22
• Purity: ≥95%
• Synonyms: 3-(2,3,4,5-tetrahydropyridin-6-yl)pyridine
• InChI: InChI=1S/C10H12N2/c1-2-7-12-10(5-1)9-4-3-6-11-8-9/h3-4,6,8H,1-2,5,7H2
• InChIKey: AUBPMADJYNSPOA-UHFFFAOYSA-N
• SMILES: C1CCN=C(C1)C2=CN=CC=C2

Anabaseine (Cat No.: R001632) is a naturally occurring piperidine alkaloid found in some marine worms and tobacco species, recognized for its activity as a nicotinic acetylcholine receptor (nAChR) agonist. It interacts with multiple nAChR subtypes, influencing neuromuscular transmission and central nervous system signaling. Anabaseine and its synthetic derivatives, such as GTS-21 (DMXBA), have been studied for potential therapeutic applications in Alzheimer’s disease, schizophrenia, and cognitive enhancement. As a pharmacological tool, Anabaseine is widely used to investigate cholinergic neurotransmission, receptor pharmacology, and neurotherapeutic development.

Reference

[1]. Kem W, et al. The Nemertine Toxin Anabaseine and Its Derivative DMXBA (GTS-21): Chemical and Pharmacological Properties. Mar Drugs. 2006;4(3):255-273.

[2]. Summers KL et al. Nicotinic agonist modulation of neurotransmitter levels in the rat frontoparietal cortex. Jpn J Pharmacol. 1997 Jun;74(2):139-46.
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[3]. Andrud K, et al. Investigation of the Possible Pharmacologically Active Forms of the Nicotinic Acetylcholine Receptor Agonist Anabaseine. Mar Drugs. 2019;17(11):614. Published 2019 Oct 29.
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