AMTB hydrochloride

• CAT Number: I010871
• CAS Number: 926023-82-7
• Molecular Formula: C23H27ClN2O2S
• Molecular Weight: 430.99
• Purity: ≥95%
• Synonyms: N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(thiophen-2-ylmethyl)benzamide;hydrochloride
• InChI: InChI=1S/C23H26N2O2S.ClH/c1-18-7-4-8-19(15-18)17-27-22-11-3-2-10-21(22)23(26)25(13-6-12-24)16-20-9-5-14-28-20;/h2-5,7-11,14-15H,6,12-13,16-17,24H2,1H3;1H
• InChIKey: UDXGBANGPYONOK-UHFFFAOYSA-N
• SMILES: CC1=CC(=CC=C1)COC2=CC=CC=C2C(=O)N(CCCN)CC3=CC=CS3.Cl

AMTB hydrochloride (Cat No.: I010871) is a selective antagonist of the transient receptor potential melastatin 8 (TRPM8) channel, which is activated by cold temperatures and menthol. By blocking TRPM8, AMTB is used in research to study cold sensation, thermoregulation, and pain perception. It has potential applications in understanding and treating conditions such as cold allodynia and neuropathic pain. AMTB hydrochloride is primarily used in experimental settings and is not approved for clinical use. Side effects and toxicity profiles are still under investigation.

Reference

[1]. Lashinger ES, et al. AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome. Am J Physiol Renal Physiol. 2008;295(3):F803-F810.
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[2]. Yapa KTDS, et al. Assessment of the TRPM8 inhibitor AMTB in breast cancer cells and its identification as an inhibitor of voltage gated sodium channels. Life Sci. 2018;198:128-135.
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