For research use only. Not for therapeutic Use.
Amoscanate (Cat No.: I022107) is an experimental anthelmintic compound belonging to the aryl isothiocyanate class, investigated for the treatment of schistosomiasis caused by Schistosoma parasites. It acts by covalently modifying parasite proteins, disrupting essential enzymatic functions, and impairing worm survival. Amoscanate demonstrated potent activity against both adult and immature schistosomes in preclinical studies. However, concerns about toxicity limited its clinical development. It remains of interest in antiparasitic drug research as a lead structure for designing safer derivatives targeting helminth infections in tropical and subtropical regions.
| CAS Number | 26328-53-0 |
| Synonyms | 4-isothiocyanato-N-(4-nitrophenyl)aniline |
| Molecular Formula | C13H9N3O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C13H9N3O2S/c17-16(18)13-7-5-12(6-8-13)15-11-3-1-10(2-4-11)14-9-19/h1-8,15H |
| InChIKey | DKVNAGXPRSYHLB-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1NC2=CC=C(C=C2)[N+](=O)[O-])N=C=S |
| Reference | [1]. Johanson C, et al. The distributional nexus of choroid plexus to cerebrospinal fluid, ependyma and brain: toxicologic/pathologic phenomena, periventricular destabilization, and lesion spread. Toxicol Pathol. 2011;39(1):186-212. |
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