Amlodipine-1,1,2,2-d4 maleate

• CAT Number: R004859
• CAS Number: 1185246-15-4
• Molecular Formula: C24H25D4ClN2O9
• Molecular Weight: 528.97
• Purity: ≥95%
• Synonyms: (Z)-but-2-enedioic acid;3-O-ethyl 5-O-methyl 2-[(2-amino-1,1,2,2-tetradeuterioethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
• InChI: InChI=1S/C20H25ClN2O5.C4H4O4/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;5-3(6)1-2-4(7)8/h5-8,17,23H,4,9-11,22H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/i9D2,10D2
• InChIKey: TZNOWAJJWCGILX-IBTKSTAFSA-N
• SMILES: [2H]C([2H])(C([2H])([2H])OCC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2Cl)C(=O)OCC)N.C(=C\C(=O)O)\C(=O)O

Amlodipine-1,1,2,2-d4 maleate（Cat No.:R004859）is a deuterium-labeled form of amlodipine, a long-acting calcium channel blocker used to treat hypertension and angina. This compound includes four deuterium atoms at specific carbon positions, enhancing stability and enabling precise detection in mass spectrometry-based pharmacokinetic studies. The maleate salt form improves solubility and handling for laboratory use. Amlodipine-1,1,2,2-d4 retains the pharmacological activity of the parent drug, inhibiting L-type calcium channels to relax vascular smooth muscle. It is widely used in bioanalytical research to monitor drug metabolism, distribution, and therapeutic equivalence in clinical and preclinical models.