Aminooxy-PEG3-C2-thiol

• CAT Number: I014058
• CAS Number: 1200365-63-4
• Molecular Formula: C8H19NO4S
• Molecular Weight: 225.31
• Purity: ≥95%
• Synonyms: O-[2-[2-[2-(2-sulfanylethoxy)ethoxy]ethoxy]ethyl]hydroxylamine
• InChI: InChI=1S/C8H19NO4S/c9-13-6-5-11-2-1-10-3-4-12-7-8-14/h14H,1-9H2
• InChIKey: PPTKPSRJLDTYOY-UHFFFAOYSA-N
• SMILES: C(COCCON)OCCOCCS

Aminooxy-PEG3-C2-thiol（Cat No.:I014058）is a heterobifunctional polyethylene glycol linker featuring an aminooxy group on one end and a thiol group on the other, separated by a short C2 alkyl spacer and a PEG3 chain. The aminooxy moiety reacts selectively with aldehydes or ketones to form stable oxime linkages, while the thiol group enables conjugation to maleimide- or disulfide-containing molecules. The PEG3 spacer enhances water solubility, reduces steric hindrance, and improves molecular flexibility. This reagent is widely used in bioconjugation, protein labeling, and drug delivery research, enabling site-specific and stable macromolecule modifications.