Aminooxy-amido-PEG4-propargyl

• CAT Number: I016250
• CAS Number: 2253965-03-4
• Molecular Formula: C13H24N2O6
• Molecular Weight: 304.34
• Purity: ≥95%
• Synonyms: 2-aminooxy-N-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethyl]acetamide
• InChI: InChI=1S/C13H24N2O6/c1-2-4-17-6-8-19-10-11-20-9-7-18-5-3-15-13(16)12-21-14/h1H,3-12,14H2,(H,15,16)
• InChIKey: FHURZUINFBYFMV-UHFFFAOYSA-N
• SMILES: C#CCOCCOCCOCCOCCNC(=O)CON

Aminooxy-amido-PEG4-propargyl(CAT: I016250) is a multifunctional PEG-based linker featuring an aminooxy group and a terminal propargyl moiety, separated by a four-unit polyethylene glycol (PEG4) spacer. The aminooxy functionality enables chemoselective oxime ligation with aldehydes and ketones under mild conditions, forming stable oxime linkages. The propargyl group provides an alkyne handle for copper-catalyzed azide–alkyne cycloaddition (CuAAC) or strain-promoted click reactions with azides, allowing orthogonal conjugation strategies. The PEG4 spacer enhances solubility, flexibility, and biocompatibility, reducing steric hindrance in complex biological systems. Aminooxy-amido-PEG4-propargyl is highly valuable for inhibitor synthesis, site-specific drug conjugates, and bioorthogonal probe development in cancer, immunology, and metabolic disease research.