For research use only. Not for therapeutic Use.
Aminohexylgeldanamycin (Cat No.: I045310) is a synthetic derivative of geldanamycin, a benzoquinone ansamycin antibiotic known for its potent inhibition of heat shock protein 90 (Hsp90). The addition of an aminohexyl side chain enhances its water solubility and cellular uptake, making it a valuable tool in cancer research. By disrupting Hsp90 function, it leads to the degradation of oncogenic client proteins. Aminohexylgeldanamycin is used in preclinical studies to explore anti-tumor activity and investigate molecular chaperone pathways in cancer cell biology.
| CAS Number | 485395-71-9 |
| Synonyms | [(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(6-aminohexylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate |
| Molecular Formula | C34H52N4O8 |
| Purity | ≥95% |
| InChI | InChI=1S/C34H52N4O8/c1-20-16-24-29(37-15-10-8-7-9-14-35)26(39)19-25(31(24)41)38-33(42)21(2)12-11-13-27(44-5)32(46-34(36)43)23(4)18-22(3)30(40)28(17-20)45-6/h11-13,18-20,22,27-28,30,32,37,40H,7-10,14-17,35H2,1-6H3,(H2,36,43)(H,38,42)/b13-11-,21-12+,23-18+/t20-,22+,27+,28+,30-,32+/m1/s1 |
| InChIKey | FEKZHEHNADINKB-OLLHKAICSA-N |
| SMILES | CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCCCCCN)C)OC)OC(=O)N)C)C)O)OC |
| Reference | [1]. Greish K, et al. Anticancer and antiangiogenic activity of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer therapy. J Control Release. 2011;151(3):263-270. [2]. Larson N, et al. HPMA copolymer-aminohexylgeldanamycin conjugates targeting cell surface expressed GRP78 in prostate cancer. Pharm Res. 2010;27(12):2683-2693. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
