Amino-PEG7-t-butyl ester

• CAT Number: I045407
• CAS Number: 2428400-07-9
• Molecular Formula: C21H43NO9
• Molecular Weight: 453.57
• Purity: ≥95%
• Synonyms: tert-butyl 3-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C21H43NO9/c1-21(2,3)31-20(23)4-6-24-8-10-26-12-14-28-16-18-30-19-17-29-15-13-27-11-9-25-7-5-22/h4-19,22H2,1-3H3
• InChIKey: DQPAYUNKPDINFW-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCN

Amino-PEG7-t-butyl ester (Cat No.: I045407) is a heterobifunctional polyethylene glycol (PEG) linker composed of seven ethylene glycol units, providing high flexibility and hydrophilicity. It features a terminal primary amine for conjugation with activated esters or carboxyl groups, and a t-butyl ester-protected carboxylic acid that can be deprotected under acidic conditions to yield a free acid. The PEG spacer minimizes steric hindrance and improves solubility, making this reagent ideal for bioconjugation, drug delivery system design, and the synthesis of multifunctional biomolecules in chemical and biomedical research.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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