Amino-PEG2-(CH2)3COOH

• CAT Number: I014089
• CAS Number: 1263046-77-0
• Molecular Formula: C8H17NO4
• Molecular Weight: 191.22
• Purity: ≥95%
• Synonyms: 4-[2-(2-aminoethoxy)ethoxy]butanoic acid
• InChI: InChI=1S/C8H17NO4/c9-3-5-13-7-6-12-4-1-2-8(10)11/h1-7,9H2,(H,10,11)
• InChIKey: CDXINNRZABLVDW-UHFFFAOYSA-N
• SMILES: C(CC(=O)O)COCCOCCN

Amino-PEG2-(CH2)3COOH（Cat No.:I014089）is a heterobifunctional linker combining a primary amine and a terminal carboxylic acid separated by a short PEG2 spacer and a propyl segment. The amine reacts readily with NHS esters, activated carboxyls (EDC/NHS), isocyanates, epoxides, or aldehydes (reductive amination). The carboxyl group enables efficient amide formation with amines using carbodiimide chemistry, allowing orthogonal, sequential conjugation. The PEG2 unit enhances aqueous solubility and flexibility, while the (CH2)3 segment introduces hydrophobic spacing. Ideal for modular bioconjugation, protein or peptide labeling, nanoparticle and surface modification, hydrogel crosslinking, and probe or drug–linker construction.