Amifostine trihydrate

• CAT Number: I002179
• CAS Number: 112901-68-5
• Molecular Formula: C5H21N2O6PS
• Molecular Weight: 268.27
• Purity: ≥95%
• Synonyms: [2-(3-aminopropylamino)-1-sulfanylethyl] dihydrogen phosphate;trihydrate
• IUPAC Name: 2-(3-aminopropylamino)ethylsulfanylphosphonic acid;trihydrate
• InChI: InChI=1S/C5H15N2O3PS.3H2O/c6-2-1-3-7-4-5-12-11(8,9)10;;;/h7H,1-6H2,(H2,8,9,10);3*1H2
• InChIKey: TXQPXJKRNHJWAX-UHFFFAOYSA-N
• SMILES: C(CN)CNCCSP(=O)(O)O.O.O.O

Amifostine trihydrate（Cat No.:I002179）is a cytoprotective prodrug that is dephosphorylated by alkaline phosphatase to its active thiol metabolite, WR-1065. This metabolite scavenges free radicals and provides selective protection to normal tissues against radiation-induced and chemotherapy-induced toxicity, while sparing tumor cells. Clinically, amifostine trihydrate is used to reduce xerostomia in head and neck cancer radiotherapy and to mitigate nephrotoxicity from cisplatin-based chemotherapy. In research, it serves as a key agent for exploring protective strategies against oxidative stress, DNA damage, and apoptosis in oncology and radiobiology studies.