Amifostine thiol

• CAT Number: I044652
• CAS Number: 31098-42-7
• Molecular Formula: C5H14N2S
• Molecular Weight: 134.24
• Purity: ≥95%
• Synonyms: 2-(3-aminopropylamino)ethanethiol
• InChI: InChI=1S/C5H14N2S/c6-2-1-3-7-4-5-8/h7-8H,1-6H2
• InChIKey: YHPLKWQJMAYFCN-UHFFFAOYSA-N
• SMILES: C(CN)CNCCS

Amifostine thiol（Cat No.:I044652）is the active free thiol metabolite of amifostine, a cytoprotective agent used to reduce the toxic side effects of chemotherapy and radiation therapy. It is formed in vivo through dephosphorylation by alkaline phosphatases and acts as a potent free radical scavenger and nucleophile. Amifostine thiol selectively protects normal tissues by neutralizing reactive oxygen species and binding toxic electrophiles, without shielding tumor cells. Its thiol group is essential for detoxifying harmful metabolites and preventing DNA, protein, and membrane damage. It is widely studied in oncology and radioprotection research.