AMG131

• CAT Number: I002041
• CAS Number: 315224-26-1
• Molecular Formula: C21H12Cl4N2O3S
• Molecular Weight: 514.21
• Purity: ≥95%
• Synonyms: 2,4-dichloro-N-(3,5-dichloro-4-quinolin-3-yloxyphenyl)benzenesulfonamide
• InChI: InChI=1S/C21H12Cl4N2O3S/c22-13-5-6-20(16(23)8-13)31(28,29)27-14-9-17(24)21(18(25)10-14)30-15-7-12-3-1-2-4-19(12)26-11-15/h1-11,27H
• InChIKey: NMRWDFUZLLQSBN-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C=C(C=N2)OC3=C(C=C(C=C3Cl)NS(=O)(=O)C4=C(C=C(C=C4)Cl)Cl)Cl

AMG131 (Cat No.: I002041) is a small-molecule inhibitor of p38 mitogen-activated protein kinase (p38 MAPK), a key signaling enzyme involved in inflammation, stress responses, and cell differentiation. By blocking p38 MAPK activity, AMG131 reduces the production of pro-inflammatory cytokines such as TNF-α and IL-1β. It has been investigated in preclinical studies for potential therapeutic applications in autoimmune diseases, inflammatory disorders, and cancer. AMG131 is widely used as a pharmacological tool for exploring MAPK signaling, inflammation biology, and novel therapeutic approaches.

Reference

[1]. Linda S Higgins,et al. The Development of INT131 as a Selective PPARgamma Modulator: Approach to a Safer Insulin Sensitizer. PPAR Res. 2008;2008:936906.
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[2]. Alykhan Motani, et al. INT131: a selective modulator of PPAR gamma. J Mol Biol. 2009 Mar 13;386(5):1301-11.
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