AMG-548 dihydrochloride

• CAT Number: I046086
• CAS Number: 2518299-32-4
• Molecular Formula: C29H29Cl2N5O
• Molecular Weight: 534.48
• Purity: ≥95%
• Synonyms: 2-[[(2S)-2-amino-3-phenylpropyl]amino]-3-methyl-5-naphthalen-2-yl-6-pyridin-4-ylpyrimidin-4-one;dihydrochloride
• IUPAC Name: 2-[(2-amino-3-phenylpropyl)amino]-3-methyl-5-naphthalen-2-yl-6-pyridin-4-ylpyrimidin-4-one;dihydrochloride
• InChI: InChI=1S/C29H27N5O.2ClH/c1-34-28(35)26(24-12-11-21-9-5-6-10-23(21)18-24)27(22-13-15-31-16-14-22)33-29(34)32-19-25(30)17-20-7-3-2-4-8-20;;/h2-16,18,25H,17,19,30H2,1H3,(H,32,33);2*1H
• InChIKey: WQZUYJOJJJERDI-UHFFFAOYSA-N
• SMILES: CN1C(=O)C(=C(N=C1NCC(CC2=CC=CC=C2)N)C3=CC=NC=C3)C4=CC5=CC=CC=C5C=C4.Cl.Cl

AMG-548 dihydrochloride（Cat No.:I046086）is a potent and selective inhibitor of p38 mitogen-activated protein kinase (p38 MAPK), an enzyme central to inflammatory signaling pathways. By blocking p38 MAPK activity, AMG-548 reduces the production of pro-inflammatory cytokines such as TNF-α and IL-1β, making it a valuable research tool in immunology and inflammation-related studies. The dihydrochloride salt improves solubility and handling for laboratory applications. AMG-548 dihydrochloride has been investigated in preclinical and clinical research for conditions like rheumatoid arthritis, cardiovascular inflammation, and other autoimmune or inflammatory diseases.