For research use only. Not for therapeutic Use.
AMG 511(CAT:I002079) is a potent, orally available pan-inhibitor of class I phosphoinositide 3-kinases (PI3Ks), demonstrating strong activity with Ki values of 4 nM (PI3Kα), 6 nM (PI3Kβ), 2 nM (PI3Kδ), and 1 nM (PI3Kγ). By effectively suppressing PI3K signaling, AMG 511 reduces phosphorylation of Akt at Ser473, a key downstream marker of pathway inhibition. This compound exhibits robust anti-tumor efficacy in preclinical studies, notably inhibiting tumor growth in a mouse glioblastoma xenograft model. AMG 511 is a valuable tool for cancer research, particularly in studying PI3K/Akt/mTOR signaling and the development of targeted therapies against resistant tumor types.
| CAS Number | 1253573-53-3 |
| Synonyms | 4-[2-[(5-fluoro-6-methoxypyridin-3-yl)amino]-5-[(1R)-1-(4-methylsulfonylpiperazin-1-yl)ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine |
| Molecular Formula | C22H28FN9O3S |
| Purity | ≥95% |
| IUPAC Name | 4-[2-[(5-fluoro-6-methoxypyridin-3-yl)amino]-5-[(1R)-1-(4-methylsulfonylpiperazin-1-yl)ethyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine |
| InChI | InChI=1S/C22H28FN9O3S/c1-13(31-5-7-32(8-6-31)36(4,33)34)15-9-17(20-27-14(2)28-22(24)30-20)19(25-11-15)29-16-10-18(23)21(35-3)26-12-16/h9-13H,5-8H2,1-4H3,(H,25,29)(H2,24,27,28,30)/t13-/m1/s1 |
| InChIKey | KUGIFHQBIIHRIZ-CYBMUJFWSA-N |
| SMILES | CC1=NC(=NC(=N1)N)C2=C(N=CC(=C2)C(C)N3CCN(CC3)S(=O)(=O)C)NC4=CC(=C(N=C4)OC)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
