AMG-458

• CAT Number: I002074
• CAS Number: 913376-83-7
• Molecular Formula: C30H29N5O5
• Molecular Weight: 539.58
• Purity: ≥95%
• Synonyms: 1-(2-hydroxy-2-methylpropyl)-N-[5-(7-methoxyquinolin-4-yl)oxypyridin-2-yl]-5-methyl-3-oxo-2-phenylpyrazole-4-carboxamide
• InChI: InChI=1S/C30H29N5O5/c1-19-27(29(37)35(20-8-6-5-7-9-20)34(19)18-30(2,3)38)28(36)33-26-13-11-22(17-32-26)40-25-14-15-31-24-16-21(39-4)10-12-23(24)25/h5-17,38H,18H2,1-4H3,(H,32,33,36)
• InChIKey: GLBZSOQDAOLMGC-UHFFFAOYSA-N
• SMILES: CC1=C(C(=O)N(N1CC(C)(C)O)C2=CC=CC=C2)C(=O)NC3=NC=C(C=C3)OC4=C5C=CC(=CC5=NC=C4)OC

AMG-458（Cat No.:I002074）is a potent and selective small-molecule inhibitor of the c-Met receptor tyrosine kinase, which plays a critical role in tumor growth, angiogenesis, and metastasis. By blocking hepatocyte growth factor (HGF)-mediated c-Met activation, AMG-458 suppresses downstream signaling pathways including PI3K/AKT and MAPK, leading to reduced proliferation and survival of cancer cells. This compound is widely applied in oncology research to study c-Met–driven tumorigenesis and evaluate targeted therapeutic strategies. AMG-458 serves as a valuable tool for exploring c-Met biology and advancing anticancer drug discovery.