AMG-1694

• CAT Number: I018097
• CAS Number: 1361217-07-3
• Molecular Formula: C23H30F3N3O4S2
• Molecular Weight: 533.63
• Purity: ≥95%
• Synonyms: (2R)-1,1,1-trifluoro-2-[4-[(2S)-2-[[(3S)-3-methylmorpholin-4-yl]methyl]-4-thiophen-2-ylsulfonylpiperazin-1-yl]phenyl]propan-2-ol
• InChI: InChI=1S/C23H30F3N3O4S2/c1-17-16-33-12-11-27(17)14-20-15-28(35(31,32)21-4-3-13-34-21)9-10-29(20)19-7-5-18(6-8-19)22(2,30)23(24,25)26/h3-8,13,17,20,30H,9-12,14-16H2,1-2H3/t17-,20-,22+/m0/s1
• InChIKey: OJTJLEFGCNYTBQ-RBDMOPTHSA-N
• SMILES: C[C@H]1COCCN1C[C@H]2CN(CCN2C3=CC=C(C=C3)[C@](C)(C(F)(F)F)O)S(=O)(=O)C4=CC=CS4

AMG-1694（Cat No.:I018097）is a potent antifolate agent developed as an experimental therapeutic targeting folate metabolism, a critical pathway for DNA synthesis and cell proliferation. By inhibiting folate-dependent enzymes, it disrupts nucleotide biosynthesis, leading to impaired tumor cell growth and survival. AMG-1694 has been investigated in oncology research for its potential to treat cancers reliant on folate uptake and metabolism, including leukemias and solid tumors. Its mechanism provides insights into antifolate pharmacology, resistance mechanisms, and combination strategies, making it a valuable tool in cancer drug discovery and development.