For research use only. Not for therapeutic Use.
Amelparib（Cat No.:I021947）is a selective PARP1 (poly ADP-ribose polymerase 1) inhibitor with potent anti-cancer activity, particularly in tumors exhibiting homologous recombination deficiency (HRD), such as BRCA-mutant cancers. By blocking PARP1-mediated DNA repair, Amelparib enhances DNA damage accumulation, leading to synthetic lethality in cancer cells. It shows favorable pharmacokinetics and is under investigation for use in ovarian, breast, and other solid tumors. Amelparib is used in preclinical and clinical research to explore PARP inhibition mechanisms, resistance pathways, and combination strategies with DNA-damaging agents or immune checkpoint inhibitors.
| CAS Number | 1227156-72-0 |
| Synonyms | 10-ethoxy-8-(morpholin-4-ylmethyl)-2,3,4,6-tetrahydro-1H-benzo[h][1,6]naphthyridin-5-one |
| Molecular Formula | C19H25N3O3 |
| Purity | ≥95% |
| IUPAC Name | 10-ethoxy-8-(morpholin-4-ylmethyl)-2,3,4,6-tetrahydro-1H-benzo[h][1,6]naphthyridin-5-one |
| InChI | InChI=1S/C19H25N3O3/c1-2-25-16-11-13(12-22-6-8-24-9-7-22)10-15-17(16)18-14(19(23)21-15)4-3-5-20-18/h10-11,20H,2-9,12H2,1H3,(H,21,23) |
| InChIKey | WBBZUHMHBSXBDT-UHFFFAOYSA-N |
| SMILES | CCOC1=CC(=CC2=C1C3=C(CCCN3)C(=O)N2)CN4CCOCC4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
