Ambroxol hydrochloride

• CAT Number: R003799
• CAS Number: 23828-92-4
• Molecular Formula: C13H19Br2ClN2O
• Molecular Weight: 414.566
• Purity: ≥95%
• Target: Sodium Channel
• Solubility: Limited solubility
• Storage: 3 years -20C powder
• IUPAC Name: 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol;hydrochloride
• InChI: InChI=1S/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;/h5-6,10-11,17-18H,1-4,7,16H2;1H
• InChIKey: QNVKOSLOVOTXKF-UHFFFAOYSA-N
• SMILES: C1CC(CCC1NCC2=CC(=CC(=C2N)Br)Br)O.Cl

Ambroxol HCl is a metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract.

Reference

1:Suppressive effects of the expectorant drug ambroxol hydrochloride on quartz-induced lung inflammation in F344 rats. Kanie S, Yokohira M, Yamakawa K, Nakano-Narusawa Y, Yoshida S, Hashimoto N, Imaida K.J Toxicol Pathol. 2017 Apr;30(2):153-159. doi: 10.1293/tox.2016-0050. Epub 2016 Dec 22. PMID: 28458453 Free PMC Article2:Ambroxol Hydrochloride Combined with Fluconazole Reverses the Resistance of Candida albicans to Fluconazole. Li X, Zhao Y, Huang X, Yu C, Yang Y, Sun S.Front Cell Infect Microbiol. 2017 Apr 7;7:124. doi: 10.3389/fcimb.2017.00124. eCollection 2017. PMID: 28439502 Free PMC Article3:Effects of ambroxol hydrochloride on concentrations of paclitaxel and carboplatin in lung cancer patients at different administration times. Li J, Yi W, Jiang P, Sun R, Li T.Cell Mol Biol (Noisy-le-grand). 2016 Nov 30;62(13):85-89. doi: 10.14715/cmb/2016.62.13.15. PMID: 28040066 4:Optimization of Robust HPLC Method for Quantitation of Ambroxol Hydrochloride and Roxithromycin Using a DoE Approach. Patel RB, Patel NM, Patel MR, Solanki AB.J Chromatogr Sci. 2017 Mar 1;55(3):275-283. doi: 10.1093/chromsci/bmw182. PMID: 27884873 5:Combined beta-glucosylceramide and ambroxol hydrochloride in patients with Gaucher related Parkinson disease: From clinical observations to drug development. Ishay Y, Zimran A, Szer J, Dinur T, Ilan Y, Arkadir D.Blood Cells Mol Dis. 2016 Nov 12. pii: S1079-9796(16)30229-7. doi: 10.1016/j.bcmd.2016.10.028. [Epub ahead of print] PMID: 27866808 6:Validated derivative and ratio derivative spectrophotometric methods for the simultaneous determination of levocetirizine dihydrochloride and ambroxol hydrochloride in pharmaceutical dosage form. Ali OI, Ismail NS, Elgohary RM.Spectrochim Acta A Mol Biomol Spectrosc. 2016 Jan 15;153:605-11. doi: 10.1016/j.saa.2015.09.014. Epub 2015 Sep 25. PMID: 26439526 7:[Incompatibility with vancomycin hydrochloride and ambroxol hydrochloride injection]. Zhong X, Xie X.Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Jun;27(6):537. doi: 10.3760/cma. j. issn.2095-4352.2015.06.025. Chinese. No abstract available. PMID: 26049200 Free Article8:Monitoring of the manufacturing process for ambroxol hydrochloride tablet using NIR-chemometric methods: compression effect on content uniformity model and relevant process parameters testing. Yang H, Liao X, Peng F, Wang W, Liu Y, Yan J, Li H.Drug Dev Ind Pharm. 2015;41(11):1877-87. doi: 10.3109/03639045.2015.1019354. Epub 2015 Mar 4. PMID: 25738811 9:Ambroxol hydrochloride in the management of idiopathic pulmonary fibrosis: Clinical trials are the need of the hour. Gupta PR.Lung India. 2014 Jan;31(1):43-6. doi: 10.4103/0970-2113.125899. PMID: 24669082 Free PMC Article10:Development and validation of an high-performance liquid chromatographic, and a ultraviolet spectrophotometric method for determination of Ambroxol hydrochloride in pharmaceutical preparations. Muralidharan S, Kumar JR, Dhanara SA.J Adv Pharm Technol Res. 2013 Jan;4(1):65-8. doi: 10.4103/2231-4040.107503. PMID: 23662284 Free PMC Article