• CAT Number: I000150
  • CAS Number: 102121-60-8
  • Molecular Formula: C22H25NO3
  • Molecular Weight: 351.44
  • Purity: ≥95%
Inquiry Now

AM580(Cat No.:I000150), also known as Ro 40-6055; NSC608001; CD336, is a stable retinoic acid derivative originally synthesized as a RARα agonist. AM580 is also a potent inducer of granulocyte maturation in NB4 (an APL-derived cell line) and freshly isolated APL blasts.

Catalog Number I000150
CAS Number 102121-60-8
Molecular Formula


Purity 95%
Target RAR/RXR
Solubility DMSO: ≥ 45 mg/mL
Storage -20°C
IUPAC Name 4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalene-2-carbonyl)amino]benzoic acid
InChI InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)

</br>1:Reversal by RARα agonist Am580 of c-Myc-induced imbalance in RARα/RARγ expression during MMTV-Myc tumorigenesis. Bosch A, Bertran SP, Lu Y, Garcia A, Jones AM, Dawson MI, Farias EF.Breast Cancer Res. 2012 Aug 24;14(4):R121. doi: 10.1186/bcr3247. PMID: 22920668 Free PMC Article</br>2:Mechanism of inhibition of MMTV-neu and MMTV-wnt1 induced mammary oncogenesis by RARalpha agonist AM580. Lu Y, Bertran S, Samuels TA, Mira-y-Lopez R, Farias EF.Oncogene. 2010 Jun 24;29(25):3665-76. doi: 10.1038/onc.2010.119. Epub 2010 May 10. PMID: 20453882 Free PMC Article</br>3:Synthesis and pharmacological characterization of Disila-AM80 (Disila-tamibarotene) and Disila-AM580, silicon analogues of the RARalpha-selective retinoid agonists AM80 (Tamibarotene) and AM580. Tacke R, Müller V, Büttner MW, Lippert WP, Bertermann R, Daiss JO, Khanwalkar H, Furst A, Gaudon C, Gronemeyer H.ChemMedChem. 2009 Nov;4(11):1797-802. doi: 10.1002/cmdc.200900257. No abstract available. PMID: 19790202 </br>4:AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells. Gianní M, Li Calzi M, Terao M, Guiso G, Caccia S, Barbui T, Rambaldi A, Garattini E.Blood. 1996 Feb 15;87(4):1520-31. PMID: 8608243 Free Article</br>5:Determination of the retinobenzoic acid derivative Am580 in rat plasma by high-performance liquid chromatography. Dimitrova B, Caccia S, Garattini E, Guiso G.J Chromatogr B Biomed Appl. 1995 May 19;667(2):301-6. PMID: 7663703 </br>6:Synthetic retinoids, retinobenzoic acids, Am80, Am580 and Ch55 regulate morphogenesis in chick limb bud. Tamura K, Kagechika H, Hashimoto Y, Shudo K, Ohsugi K, Ide H.Cell Differ Dev. 1990 Oct;32(1):17-26. PMID: 2090329

Request a Quote

Contact Us at MuseChem

We are committed to providing you with reliable, cost-effective solutions for your chemical needs, while ensuring your safety and comfort. Our team of experts is always available to answer your questions and help you navigate the complexities of the chemical industry.

Whether you're looking for a specific product or need help with a custom synthesis project, we're here to help you discover a new world of chemical possibilities. Contact us today to learn more about how we can assist you with all of your chemical needs.

Our goal is to make the process of ordering chemicals as seamless and hassle-free as possible. Let us know how we can assist you, and we'll get back to you as soon as possible. We look forward to hearing from you!