For research use only. Not for therapeutic Use.
ALV2（Cat No.:I044682）is a small-molecule inhibitor designed to target leucine-rich repeat kinase 2 (LRRK2), a protein kinase implicated in the pathogenesis of Parkinson’s disease. By selectively inhibiting LRRK2’s kinase activity, ALV2 reduces aberrant phosphorylation of downstream substrates associated with neuroinflammation, mitochondrial dysfunction, and neuronal degeneration. Preclinical studies have shown that ALV2 can attenuate pathological LRRK2 signaling and improve neuronal health without significant toxicity. Its favorable pharmacokinetic profile and brain penetrance make ALV2 a promising candidate for disease-modifying therapy aimed at treating familial and sporadic forms of Parkinson’s disease.
| CAS Number | 2438124-95-7 |
| Synonyms | 1-(3-chloro-4-methylphenyl)-3-[2-[3-[[1-(2,6-dioxopiperidin-3-yl)-2,5-dioxopyrrol-3-yl]amino]phenyl]propan-2-yl]urea |
| Molecular Formula | C26H26ClN5O5 |
| Purity | ≥95% |
| IUPAC Name | 1-(3-chloro-4-methylphenyl)-3-[2-[3-[[1-(2,6-dioxopiperidin-3-yl)-2,5-dioxopyrrol-3-yl]amino]phenyl]propan-2-yl]urea |
| InChI | InChI=1S/C26H26ClN5O5/c1-14-7-8-17(12-18(14)27)29-25(37)31-26(2,3)15-5-4-6-16(11-15)28-19-13-22(34)32(24(19)36)20-9-10-21(33)30-23(20)35/h4-8,11-13,20,28H,9-10H2,1-3H3,(H2,29,31,37)(H,30,33,35) |
| InChIKey | YKFHBIMJVFQOQL-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=C1)NC(=O)NC(C)(C)C2=CC(=CC=C2)NC3=CC(=O)N(C3=O)C4CCC(=O)NC4=O)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
