alpha-GalNAc-TEG-N3

• CAT Number: I042566
• CAS Number: 882873-70-3
• Molecular Formula: C14H26N4O8
• Molecular Weight: 378.38
• Purity: ≥95%
• Synonyms: N-[(2S,3R,4R,5R,6R)-2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
• InChI: InChI=1S/C14H26N4O8/c1-9(20)17-11-13(22)12(21)10(8-19)26-14(11)25-7-6-24-5-4-23-3-2-16-18-15/h10-14,19,21-22H,2-8H2,1H3,(H,17,20)/t10-,11-,12+,13-,14+/m1/s1
• InChIKey: FLYIOTWDNWJXHY-RGDJUOJXSA-N
• SMILES: CC(=O)NC1C(C(C(OC1OCCOCCOCCN=[N+]=[N-])CO)O)O

α-GalNAc-TEG-N₃ (Cat No.: I042566) is a synthetic glycosylated molecule consisting of N-acetyl-α-D-galactosamine (α-GalNAc) linked via a triethylene glycol (TEG) spacer to an azide (N₃) functional group. The α-GalNAc moiety mimics the Tn antigen, a key structure in glycoproteins involved in cancer and immune recognition. The TEG spacer enhances solubility and flexibility, while the azide group enables bioorthogonal conjugation via click chemistry. This compound is valuable in glycan-based labeling, targeted drug delivery, vaccine design, and probing glycan-protein interactions in biomedical research.

Reference

[1]. Jiang X, et al. Recent applications of click chemistry in drug discovery. Expert Opin Drug Discov. 2019 Aug;14(8):779-789.
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