For research use only. Not for therapeutic Use.
ALK5-IN-8（Cat No.:I044068）is a potent and selective inhibitor of activin receptor-like kinase 5 (ALK5), also known as TGF-β type I receptor, a key mediator in the TGF-β signaling pathway. By blocking ALK5 kinase activity, ALK5-IN-8 inhibits Smad2/3 phosphorylation, thereby suppressing fibrotic, immunosuppressive, and pro-oncogenic effects driven by TGF-β. This compound is widely used in research on cancer, fibrosis, and epithelial-to-mesenchymal transition (EMT). ALK5-IN-8 serves as a valuable tool for dissecting TGF-β-related mechanisms and exploring therapeutic strategies targeting tumor stroma remodeling and immune resistance in the tumor microenvironment.
| CAS Number | 2705900-81-6 |
| Synonyms | ethyl 5-[5-(4-fluorophenyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyridine-3-carboxylate |
| Molecular Formula | C19H15FN4O2 |
| Purity | ≥95% |
| IUPAC Name | ethyl 5-[5-(4-fluorophenyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyridine-3-carboxylate |
| InChI | InChI=1S/C19H15FN4O2/c1-2-26-19(25)16-11-22-24-8-7-13(9-17(16)24)15-10-21-23-18(15)12-3-5-14(20)6-4-12/h3-11H,2H2,1H3,(H,21,23) |
| InChIKey | GFFVSPZTWRNCIU-UHFFFAOYSA-N |
| SMILES | CCOC(=O)C1=C2C=C(C=CN2N=C1)C3=C(NN=C3)C4=CC=C(C=C4)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
