Alamandine

• CAT Number: I044238
• CAS Number: 1176306-10-7
• Molecular Formula: C40H62N12O9
• Molecular Weight: 855.00
• Purity: ≥95%
• Synonyms: (2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carboxylic acid
• InChI: InChI=1S/C40H62N12O9/c1-6-22(4)32(37(58)49-29(18-25-19-44-20-46-25)38(59)52-16-8-10-30(52)39(60)61)51-35(56)28(17-24-11-13-26(53)14-12-24)48-36(57)31(21(2)3)50-34(55)27(47-33(54)23(5)41)9-7-15-45-40(42)43/h11-14,19-23,27-32,53H,6-10,15-18,41H2,1-5H3,(H,44,46)(H,47,54)(H,48,57)(H,49,58)(H,50,55)(H,51,56)(H,60,61)(H4,42,43,45)/t22-,23-,27-,28-,29-,30-,31-,32-/m0/s1
• InChIKey: QVMYBFKDLPBYSO-GIGALADGSA-N
• SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)O)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)N

Alamandine（Cat No.:I044238）is a bioactive heptapeptide of the renin–angiotensin system (RAS), structurally similar to angiotensin-(1–7), but with an N-terminal alanine replacing aspartate. It exerts its physiological effects primarily through the Mas-related G protein-coupled receptor D (MrgD), promoting vasodilation, anti-fibrotic, and cardioprotective actions. Alamandine counteracts the harmful effects of angiotensin II, such as hypertension and inflammation, making it a focus of cardiovascular and renal research. Its role in modulating vascular tone, oxidative stress, and metabolic balance positions it as a promising candidate for therapeutic strategies targeting RAS-related disorders.