For research use only. Not for therapeutic Use.
Alafosfalin（Cat No.:M021338）is a synthetic dipeptide antibiotic composed of L-alanine and L-1-aminoethylphosphonic acid (fosfalin). It acts as a prodrug, transported into bacterial cells via peptide permeases, where it is hydrolyzed to release fosfalin, an inhibitor of alanine racemase. By blocking this enzyme, alafosfalin disrupts bacterial cell wall biosynthesis, exerting antibacterial activity, particularly against Gram-positive and some Gram-negative organisms. It has been studied as a potential therapeutic for resistant infections and also serves as a research tool for investigating phosphonate chemistry, antibiotic design, and peptide-based drug delivery mechanisms.
| CAS Number | 60668-24-8 |
| Synonyms | [(1R)-1-[[(2S)-2-aminopropanoyl]amino]ethyl]phosphonic acid |
| Molecular Formula | C5H13N2O4P |
| Purity | ≥95% |
| IUPAC Name | [(1R)-1-[[(2S)-2-aminopropanoyl]amino]ethyl]phosphonic acid |
| InChI | InChI=1S/C5H13N2O4P/c1-3(6)5(8)7-4(2)12(9,10)11/h3-4H,6H2,1-2H3,(H,7,8)(H2,9,10,11)/t3-,4+/m0/s1 |
| InChIKey | BHAYDBSYOBONRV-IUYQGCFVSA-N |
| SMILES | C[C@@H](C(=O)N[C@@H](C)P(=O)(O)O)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
