For research use only. Not for therapeutic Use.
Aladorian (CAT: R036607) is a benzothiazepine-derived small molecule that acts as a potent blocker of ryanodine receptor 2 (RyR2), and also modulates RyR1 and RyR3. It exhibits promising anti-arrhythmic activity and is used in research exploring heart failure and catecholaminergic polymorphic ventricular tachycardia (CPVT). As a RyR modulator, Aladorian stabilizes intracellular calcium handling—an essential mechanism in cardiac rhythm control—making it a valuable tool in cardiovascular disease research. Its oral bioavailability and advancement into Phase II clinical trials further underscore its relevance in exploring targeted therapeutic strategies for ventricular arrhythmias and heart dysfunction.
| CAS Number | 865433-00-7 |
| Synonyms | 2-(7-methoxy-3,5-dihydro-2H-1,4-benzothiazepin-4-yl)-2-oxoacetic acid |
| Molecular Formula | C12H13NO4S |
| Purity | ≥95% |
| IUPAC Name | 2-(7-methoxy-3,5-dihydro-2H-1,4-benzothiazepin-4-yl)-2-oxoacetic acid |
| InChI | InChI=1S/C12H13NO4S/c1-17-9-2-3-10-8(6-9)7-13(4-5-18-10)11(14)12(15)16/h2-3,6H,4-5,7H2,1H3,(H,15,16) |
| InChIKey | FPWBHFYYVSNIFZ-UHFFFAOYSA-N |
| SMILES | COC1=CC2=C(C=C1)SCCN(C2)C(=O)C(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
