AK-778-XXMU

For research use only. Not for therapeutic Use.

  • CAT Number: I044042
  • CAS Number: 1227045-76-2
  • Molecular Formula: C22H17ClN2O3
  • Molecular Weight: 392.83
  • Purity: ≥95%
Inquiry Now

AK-778-XXMU(Cat No.:I044042)is a selective and potent small-molecule inhibitor of the IDO1 (indoleamine 2,3-dioxygenase 1) enzyme, which plays a central role in immune evasion by catalyzing the degradation of tryptophan to immunosuppressive kynurenine. By blocking IDO1 activity, AK-778-XXMU restores T-cell proliferation and promotes anti-tumor immune responses, making it valuable in cancer immunotherapy research. It is particularly relevant in studies aiming to overcome immune tolerance in the tumor microenvironment and enhance the efficacy of immune checkpoint inhibitors. AK-778-XXMU supports therapeutic exploration of IDO1 inhibition in various oncologic and inflammatory contexts.


CAS Number 1227045-76-2
Synonyms

1-[(3-chlorophenyl)methyl]-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)indol-2-one

Molecular Formula C22H17ClN2O3
Purity ≥95%
IUPAC Name 1-[(3-chlorophenyl)methyl]-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)indol-2-one
InChI InChI=1S/C22H17ClN2O3/c23-16-7-5-6-15(12-16)14-25-19-10-2-1-8-17(19)22(28,21(25)27)13-20(26)18-9-3-4-11-24-18/h1-12,28H,13-14H2
InChIKey JJOIKBZRLCEZOR-UHFFFAOYSA-N
SMILES C1=CC=C2C(=C1)C(C(=O)N2CC3=CC(=CC=C3)Cl)(CC(=O)C4=CC=CC=N4)O
Chemistry Calculators Dilution Calculator
In vivo Formulation Calculator
Molarity Calculator
Molecular Weight Calculator
Reconstitution Calculator

Request a Quote