AHR antagonist 5

• CAT Number: I015472
• CAS Number: 2247953-39-3
• Molecular Formula: C25H27Cl3FN7
• Molecular Weight: 550.89
• Purity: ≥95%
• Synonyms: (3R)-N-[2-(5-fluoropyridin-3-yl)-8-propan-2-ylpyrazolo[1,5-a][1,3,5]triazin-4-yl]-2,3,4,9-tetrahydro-1H-carbazol-3-amine;trihydrochloride
• InChI: InChI=1S/C25H24FN7.3ClH/c1-14(2)20-13-28-33-24(20)31-23(15-9-16(26)12-27-11-15)32-25(33)29-17-7-8-22-19(10-17)18-5-3-4-6-21(18)30-22;;;/h3-6,9,11-14,17,30H,7-8,10H2,1-2H3,(H,29,31,32);3*1H/t17-;;;/m1.../s1
• InChIKey: SRGGKFXUJGRKIJ-NMRXSTGRSA-N
• SMILES: CC(C)C1=C2N=C(N=C(N2N=C1)N[C@@H]3CCC4=C(C3)C5=CC=CC=C5N4)C6=CC(=CN=C6)F.Cl.Cl.Cl

AHR Antagonist 5（Cat No.:I015472）is a small-molecule inhibitor designed to block the activity of the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor involved in xenobiotic metabolism, immune regulation, and cancer progression. By antagonizing AHR, it prevents receptor-mediated gene expression, including cytochrome P450 enzymes, and modulates downstream signaling linked to tumor growth, inflammation, and immune suppression. AHR Antagonist 5 is primarily used in cancer biology, immunology, and toxicology research, providing a valuable tool to dissect AHR-dependent pathways and evaluate its therapeutic potential in disease intervention strategies.