AHR antagonist 5 free base

For research use only. Not for therapeutic Use.

  • CAT Number: I045261
  • CAS Number: 2247950-42-9
  • Molecular Formula: C25H24FN7
  • Molecular Weight: 441.50
  • Purity: ≥95%
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AHR Antagonist 5 free base(Cat No.:I045261)is a potent small-molecule inhibitor of the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor involved in xenobiotic metabolism, immune regulation, and cancer biology. By blocking AHR activation, it prevents transcription of downstream target genes such as CYP1A1, modulating pathways linked to inflammation, tumor progression, and toxic responses to environmental pollutants. The free base form offers improved handling for certain experimental setups. This compound is valuable for studying AHR signaling in immunology, oncology, and toxicology, as well as for developing therapeutic strategies targeting AHR-driven pathologies.


CAS Number 2247950-42-9
Synonyms

(3R)-N-[2-(5-fluoropyridin-3-yl)-8-propan-2-ylpyrazolo[1,5-a][1,3,5]triazin-4-yl]-2,3,4,9-tetrahydro-1H-carbazol-3-amine

Molecular Formula C25H24FN7
Purity ≥95%
IUPAC Name (3R)-N-[2-(5-fluoropyridin-3-yl)-8-propan-2-ylpyrazolo[1,5-a][1,3,5]triazin-4-yl]-2,3,4,9-tetrahydro-1H-carbazol-3-amine
InChI InChI=1S/C25H24FN7/c1-14(2)20-13-28-33-24(20)31-23(15-9-16(26)12-27-11-15)32-25(33)29-17-7-8-22-19(10-17)18-5-3-4-6-21(18)30-22/h3-6,9,11-14,17,30H,7-8,10H2,1-2H3,(H,29,31,32)/t17-/m1/s1
InChIKey QPFPBVPZIIDXGT-QGZVFWFLSA-N
SMILES CC(C)C1=C2N=C(N=C(N2N=C1)N[C@@H]3CCC4=C(C3)C5=CC=CC=C5N4)C6=CC(=CN=C6)F
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