For research use only. Not for therapeutic Use.
AGN 192870（Cat No.:I044179）is a selective antagonist of retinoic acid receptor gamma (RARγ), one of the nuclear receptors involved in regulating gene expression during development, differentiation, and cell proliferation. By inhibiting RARγ, AGN 192870 modulates retinoid signaling pathways, which are critical in processes like skin biology and skeletal development. It has been used in research to explore the role of RARγ in dermatological conditions, cancer, and retinoid-induced toxicity. AGN 192870 serves as a valuable tool for dissecting receptor-specific retinoid actions and developing targeted therapies with minimized off-target effects.
| CAS Number | 166977-57-7 |
| Synonyms | 4-[2-(5,5-dimethyl-8-phenyl-6H-naphthalen-2-yl)ethynyl]benzoic acid |
| Molecular Formula | C27H22O2 |
| Purity | ≥95% |
| IUPAC Name | 4-[2-(5,5-dimethyl-8-phenyl-6H-naphthalen-2-yl)ethynyl]benzoic acid |
| InChI | InChI=1S/C27H22O2/c1-27(2)17-16-23(21-6-4-3-5-7-21)24-18-20(12-15-25(24)27)9-8-19-10-13-22(14-11-19)26(28)29/h3-7,10-16,18H,17H2,1-2H3,(H,28,29) |
| InChIKey | LTHJFFPLLKIZTC-UHFFFAOYSA-N |
| SMILES | CC1(CC=C(C2=C1C=CC(=C2)C#CC3=CC=C(C=C3)C(=O)O)C4=CC=CC=C4)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
