For research use only. Not for therapeutic Use.
AG-636（Cat No.:I021507）is a selective, oral inhibitor of dihydroorotate dehydrogenase (DHODH), a key mitochondrial enzyme in de novo pyrimidine biosynthesis. By blocking DHODH, AG-636 disrupts nucleotide production, leading to cell cycle arrest and apoptosis in rapidly proliferating cells, particularly in hematologic malignancies such as acute myeloid leukemia (AML). It also modulates epigenetic regulators and impacts leukemic stem cell viability. AG-636 has demonstrated potent anti-tumor activity in preclinical studies and is under investigation as a promising therapeutic for targeting metabolic vulnerabilities in cancer.
| CAS Number | 1623416-31-8 |
| Synonyms | 3-methyl-6-[4-(2-methylphenyl)phenyl]benzotriazole-4-carboxylic acid |
| Molecular Formula | C21H17N3O2 |
| Purity | ≥95% |
| IUPAC Name | 3-methyl-6-[4-(2-methylphenyl)phenyl]benzotriazole-4-carboxylic acid |
| InChI | InChI=1S/C21H17N3O2/c1-13-5-3-4-6-17(13)15-9-7-14(8-10-15)16-11-18(21(25)26)20-19(12-16)22-23-24(20)2/h3-12H,1-2H3,(H,25,26) |
| InChIKey | GSBZRCGZLMBSNY-UHFFFAOYSA-N |
| SMILES | CC1=CC=CC=C1C2=CC=C(C=C2)C3=CC(=C4C(=C3)N=NN4C)C(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
