AFM-30a hydrochloride

• CAT Number: I042713
• Molecular Formula: C24H28ClFN6O3
• Molecular Weight: 502.97
• Purity: ≥95%
• Synonyms: N-[(1S)-4-[(1-amino-2-fluoroethylidene)amino]-1-(4-methoxy-1-methylbenzimidazol-2-yl)butyl]-3-oxo-1,2-dihydroisoindole-4-carboxamide;hydrochloride
• InChI: InChI=1S/C24H27FN6O3.ClH/c1-31-17-9-4-10-18(34-2)21(17)30-22(31)16(8-5-11-27-19(26)12-25)29-23(32)15-7-3-6-14-13-28-24(33)20(14)15;/h3-4,6-7,9-10,16H,5,8,11-13H2,1-2H3,(H2,26,27)(H,28,33)(H,29,32);1H/t16-;/m0./s1
• InChIKey: HDGZNBCVLSJSHI-NTISSMGPSA-N
• SMILES: CN1C2=C(C(=CC=C2)OC)N=C1[C@H](CCCN=C(CF)N)NC(=O)C3=CC=CC4=C3C(=O)NC4.Cl

AFM-30a hydrochloride（Cat No.:I042713）is a selective small molecule inhibitor targeting the protein kinase CK2, which plays a crucial role in regulating cellular processes like growth, survival, and differentiation. By inhibiting CK2 activity, AFM-30a hydrochloride has potential therapeutic applications in cancer treatment, as CK2 is often overexpressed in various tumors, contributing to cancer cell proliferation and resistance to apoptosis. This compound is being explored for its ability to modulate tumor growth, improve sensitivity to chemotherapy, and potentially reduce metastasis in different types of cancer, offering a promising approach to cancer therapy.