For research use only. Not for therapeutic Use.
Afizagabar (Cat No.: I021477) is an experimental small-molecule LXR (liver X receptor) agonist being investigated for its immuno-oncology potential. By activating LXR, Afizagabar enhances innate and adaptive immune responses, particularly through the stimulation of dendritic cells and suppression of myeloid-derived suppressor cells. This dual action boosts antitumor immunity and has shown promise in preclinical cancer models. Afizagabar is used in research to explore immune modulation, cancer therapeutics, and lipid metabolism regulation, contributing to the development of next-generation oncology treatments.
| CAS Number | 1398496-82-6 |
| Synonyms | 5-(4-fluoro-1-benzothiophen-2-yl)-8-methyl-1,9-dihydro-[1,3]oxazolo[4,5-h][2,3]benzodiazepin-2-one |
| Molecular Formula | C19H12FN3O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C19H12FN3O2S/c1-9-5-10-6-14-15(25-19(24)21-14)7-11(10)18(23-22-9)17-8-12-13(20)3-2-4-16(12)26-17/h2-4,6-8H,5H2,1H3,(H,21,24) |
| InChIKey | WNUWGRVHGICCLS-UHFFFAOYSA-N |
| SMILES | CC1=NN=C(C2=CC3=C(C=C2C1)NC(=O)O3)C4=CC5=C(C=CC=C5S4)F |
| Reference | [1]. Etherington LA, et al. Selective inhibition of extra-synaptic α5-GABAA receptors by S44819, a new therapeutic agent. Neuropharmacology. 2017;125:353-364. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
