For research use only. Not for therapeutic Use.
Aficamten（Cat No.:I021474）is a selective, small-molecule cardiac myosin inhibitor developed for the treatment of hypertrophic cardiomyopathy (HCM), particularly the obstructive form. By reducing excessive cardiac contractility, Aficamten directly targets the underlying hypercontractile mechanism without affecting heart rate or rhythm. It improves cardiac output and reduces left ventricular outflow tract (LVOT) obstruction. Aficamten has shown favorable efficacy and safety in clinical trials, with a titratable dose profile that allows individualized treatment. Its mechanism provides a novel, targeted approach to managing HCM, offering an alternative to invasive procedures or broad-acting therapies.
| CAS Number | 2364554-48-1 |
| Synonyms | N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methylpyrazole-4-carboxamide |
| Molecular Formula | C18H19N5O2 |
| Purity | ≥95% |
| IUPAC Name | N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methylpyrazole-4-carboxamide |
| InChI | InChI=1S/C18H19N5O2/c1-3-16-21-17(22-25-16)12-4-6-14-11(8-12)5-7-15(14)20-18(24)13-9-19-23(2)10-13/h4,6,8-10,15H,3,5,7H2,1-2H3,(H,20,24)/t15-/m1/s1 |
| InChIKey | IOVAZWDIRCRMTM-OAHLLOKOSA-N |
| SMILES | CCC1=NC(=NO1)C2=CC3=C(C=C2)[C@@H](CC3)NC(=O)C4=CN(N=C4)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
