For research use only. Not for therapeutic Use.
ADS032(CAT: I040540) is a potent dual inhibitor of the inflammasome sensors NLRP1 and NLRP3, capable of rapidly, reversibly, and stably suppressing inflammasome activation. It effectively reduces the activation of NLRP1 and NLRP3 in human macrophages and bronchial epithelial cells, leading to decreased secretion and maturation of proinflammatory cytokines IL-1β and TNF-α. ADS032 also inhibits NLRP3-induced ASC speck formation, a hallmark of inflammasome assembly. In vivo, ADS032 provides significant protection against lethal influenza A virus infection by reducing pulmonary inflammation and improving survival. It inhibits Nigericin-induced IL-1β secretion with IC₅₀ values of 94.6 μM (no washout) and 354 μM (washout), making it a valuable tool for studying inflammasome-related immune responses and for developing anti-inflammatory therapies.
| CAS Number | 2757333-37-0 |
| Synonyms | 4-[4-[4-(dipropylsulfamoyl)phenyl]phenyl]butanoic acid |
| Molecular Formula | C22H29NO4S |
| Purity | ≥95% |
| IUPAC Name | 4-[4-[4-(dipropylsulfamoyl)phenyl]phenyl]butanoic acid |
| InChI | InChI=1S/C22H29NO4S/c1-3-16-23(17-4-2)28(26,27)21-14-12-20(13-15-21)19-10-8-18(9-11-19)6-5-7-22(24)25/h8-15H,3-7,16-17H2,1-2H3,(H,24,25) |
| InChIKey | UNMDICXGCNPMPK-UHFFFAOYSA-N |
| SMILES | CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C2=CC=C(C=C2)CCCC(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
