For research use only. Not for therapeutic Use.
ADRA1D Receptor Antagonist 1(CAT: I017334) is a potent, selective, and orally active α1D adrenoceptor antagonist with a Ki of 1.6 nM. It demonstrates significantly higher selectivity for α1D-AR over α1A- and α1B-subtypes, while exhibiting low hERG channel inhibition, indicating a favorable safety profile. In vivo, intravenous administration (4.4 µg/kg) dose-dependently reduces non-voiding bladder contractions during the urinary storage phase in a rat bladder outlet obstruction (BOO) model, highlighting its potential in urological research. By selectively modulating α1D-mediated pathways, this compound provides a valuable tool for studying lower urinary tract dysfunctions and exploring novel therapeutic strategies in urology.
| CAS Number | 1191908-14-1 |
| Synonyms | 5-chloro-1-[(1R)-1-(3-cyanophenyl)ethyl]-2-iminopyridine-3-carboxamide;hydrochloride |
| Molecular Formula | C15H14Cl2N4O |
| Purity | ≥95% |
| IUPAC Name | 5-chloro-1-[(1R)-1-(3-cyanophenyl)ethyl]-2-iminopyridine-3-carboxamide;hydrochloride |
| InChI | InChI=1S/C15H13ClN4O.ClH/c1-9(11-4-2-3-10(5-11)7-17)20-8-12(16)6-13(14(20)18)15(19)21;/h2-6,8-9,18H,1H3,(H2,19,21);1H/t9-;/m1./s1 |
| InChIKey | XUCZRJDRBBJCTE-SBSPUUFOSA-N |
| SMILES | CC(C1=CC=CC(=C1)C#N)N2C=C(C=C(C2=N)C(=O)N)Cl.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
