Adenosine receptor antagonist 2

• CAT Number: I044067
• CAS Number: 2703054-47-9
• Molecular Formula: C23H21FN8O
• Molecular Weight: 444.46
• Purity: ≥95%
• Synonyms: 3-[4-amino-5-fluoro-6-[1-[[6-(2-hydroxypropan-2-yl)pyridin-2-yl]methyl]triazol-4-yl]pyrimidin-2-yl]-2-methylbenzonitrile
• InChI: InChI=1S/C23H21FN8O/c1-13-14(10-25)6-4-8-16(13)22-28-20(19(24)21(26)29-22)17-12-32(31-30-17)11-15-7-5-9-18(27-15)23(2,3)33/h4-9,12,33H,11H2,1-3H3,(H2,26,28,29)
• InChIKey: SCLXIATZMRENPN-UHFFFAOYSA-N
• SMILES: CC1=C(C=CC=C1C2=NC(=C(C(=N2)N)F)C3=CN(N=N3)CC4=NC(=CC=C4)C(C)(C)O)C#N

Adenosine receptor antagonist 2（Cat No.:I044067）is a selective small-molecule inhibitor targeting adenosine receptors, particularly the A2A subtype, which plays a key role in immunosuppression, inflammation, and tumor progression. By blocking A2A receptor signaling, this antagonist enhances T cell activity and restores anti-tumor immune responses, making it highly relevant in cancer immunotherapy. It is also useful in studying neurodegenerative disorders and cardiovascular diseases, where adenosine pathways are implicated. Adenosine receptor antagonist 2 is a valuable tool in preclinical research for exploring adenosine signaling and evaluating immune checkpoint-resistant therapeutic strategies.