Adenosine dialdehyde

• CAT Number: I011623
• CAS Number: 34240-05-6
• Molecular Formula: C10H11N5O4
• Molecular Weight: 265.23
• Purity: ≥95%
• Synonyms: 2-[1-(6-aminopurin-9-yl)-2-oxoethoxy]-3-hydroxypropanal
• InChI: InChI=1S/C10H11N5O4/c11-9-8-10(13-4-12-9)15(5-14-8)7(3-18)19-6(1-16)2-17/h1,3-7,17H,2H2,(H2,11,12,13)
• InChIKey: ILMNSCQOSGKTNZ-UHFFFAOYSA-N
• SMILES: C1=NC(=C2C(=N1)N(C=N2)C(C=O)OC(CO)C=O)N

Adenosine dialdehyde (Cat No.: I011623) is a synthetic analog of adenosine in which the ribose moiety is oxidized to a dialdehyde. It is a potent and selective inhibitor of S-adenosylhomocysteine (SAH) hydrolase, thereby indirectly blocking methyltransferase-dependent methylation reactions. This compound is widely used in research to study epigenetic regulation, RNA processing, and enzymatic methylation pathways. By inhibiting methylation, AdOx helps elucidate mechanisms of gene expression, signal transduction, and disease processes including cancer, inflammation, and neurological disorders.

Reference

[1]. V Ramakrishnan, et al. Adenosine dialdehyde and neplanocin A: Potent inhibitors of S-adenosylhomocysteine hydrolase in neuroblastoma N2a cells. Neurochem Int. 1987;10(4):423-31.
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[2]. G V Madhavan, et al. Synthesis and antiviral evaluation of 6′-substituted aristeromycins: potential mechanism-based inhibitors of S-adenosylhomocysteine hydrolase. J Med Chem
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[3]. B Bostrom, et al. Inhibitory effect of adenosine dialdehyde on in situ murine neuroblastoma growth.Cancer Res. 1988 Nov 1;48(21):5933-6.
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