ADAMTS-5 Inhibitor

• CAT Number: R026137
• CAS Number: 929634-33-3
• Molecular Formula: C16H11ClF3N3OS3
• Molecular Weight: 449.92
• Purity: ≥95%
• Synonyms: (5Z)-5-[[5-[(4-chlorophenyl)methylsulfanyl]-1-methyl-3-(trifluoromethyl)pyrazol-4-yl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
• InChI: InChI=1S/C16H11ClF3N3OS3/c1-23-14(26-7-8-2-4-9(17)5-3-8)10(12(22-23)16(18,19)20)6-11-13(24)21-15(25)27-11/h2-6H,7H2,1H3,(H,21,24,25)/b11-6-
• InChIKey: CVYPRDPBCXSVBN-WDZFZDKYSA-N
• SMILES: CN1C(=C(C(=N1)C(F)(F)F)/C=C\2/C(=O)NC(=S)S2)SCC3=CC=C(C=C3)Cl

ADAMTS-5 Inhibitor（Cat No.:R026137）is a small-molecule compound designed to block the activity of ADAMTS-5 (a disintegrin and metalloproteinase with thrombospondin motifs-5), a key enzyme involved in cartilage degradation. Overexpression of ADAMTS-5 contributes to the breakdown of aggrecan, an essential structural component of cartilage, driving osteoarthritis and related joint diseases. By inhibiting ADAMTS-5, this compound helps preserve cartilage integrity and reduce disease progression. It is widely used in musculoskeletal research to explore disease-modifying osteoarthritis therapies and to better understand extracellular matrix regulation in degenerative conditions.