Acrivastine

  • CAT Number: I013652
  • CAS Number: 87848-99-5
  • Molecular Formula: C₂₂H₂₄N₂O₂
  • Molecular Weight: 348.44
  • Purity: ≥95%
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Acrivastine (Cat No.:I013652) is a short-acting histamine 1 receptor antagonist used in the study of allergic rhinitis. It is suitable for the treatment of allergic rhinitis, hay fever, urticaria, eczema, skin pruritus, etc.


Catalog Number I013652
CAS Number 87848-99-5
Molecular Formula C₂₂H₂₄N₂O₂
Purity ≥95%
Target Histamine Receptor
Solubility DMSO: 10.45 mg/mL (Need ultrasonic)
Storage 2-8°C
IUPAC Name (E)-3-[6-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridin-2-yl]prop-2-enoic acid
InChI InChI=1S/C22H24N2O2/c1-17-7-9-18(10-8-17)20(13-16-24-14-2-3-15-24)21-6-4-5-19(23-21)11-12-22(25)26/h4-13H,2-3,14-16H2,1H3,(H,25,26)/b12-11+,20-13+
InChIKey PWACSDKDOHSSQD-IUTFFREVSA-N
SMILES CC1=CC=C(C=C1)C(=CCN2CCCC2)C3=CC=CC(=N3)C=CC(=O)O
Reference

[1]. Brogden RN, et al. Acrivastine. A review of its pharmacological properties and therapeutic efficacy in allergic rhinitis, urticaria and related disorders. Drugs. 1991 Jun;41(6):927-40.<br>[2]. Gibbs TG, et al. Acrivastine in two doses compared with placebo in a multicentre, parallel group study for the treatment of seasonal allergic rhinitis. Br J Clin Pract. 1989 Jan;43(1):11-4.

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