For research use only. Not for therapeutic Use.
ACP-5862(CAT: I017323) is the major active circulating metabolite of Acalabrutinib, generated through pyrrolidine ring opening. It retains potent Bruton’s tyrosine kinase (BTK) inhibitory activity with an IC50 of 5 nM, closely comparable to Acalabrutinib (IC50 = 3 nM). ACP-5862 displays reversible high plasma protein binding across species (>94%) and contributes significantly to systemic drug exposure, with a half-life of ~6.9 hours and exposure levels two- to threefold higher than the parent compound in humans. As a weak, time-dependent inactivator of CYP3A4 and CYP2C8, ACP-5862 is valuable for research on B-cell malignancies, BTK signaling, and drug metabolism.
| CAS Number | 2230757-47-6 |
| Synonyms | 4-[8-amino-3-[4-(but-2-ynoylamino)butanoyl]imidazo[1,5-a]pyrazin-1-yl]-N-pyridin-2-ylbenzamide |
| Molecular Formula | C26H23N7O3 |
| Purity | ≥95% |
| IUPAC Name | 4-[8-amino-3-[4-(but-2-ynoylamino)butanoyl]imidazo[1,5-a]pyrazin-1-yl]-N-pyridin-2-ylbenzamide |
| InChI | InChI=1S/C26H23N7O3/c1-2-6-21(35)29-14-5-7-19(34)25-32-22(23-24(27)30-15-16-33(23)25)17-9-11-18(12-10-17)26(36)31-20-8-3-4-13-28-20/h3-4,8-13,15-16H,5,7,14H2,1H3,(H2,27,30)(H,29,35)(H,28,31,36) |
| InChIKey | XZAATUBTUPPERZ-UHFFFAOYSA-N |
| SMILES | CC#CC(=O)NCCCC(=O)C1=NC(=C2N1C=CN=C2N)C3=CC=C(C=C3)C(=O)NC4=CC=CC=N4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
