For research use only. Not for therapeutic Use.
Acolbifene hydrochloride（Cat No.:I021308）is a selective estrogen receptor modulator (SERM) developed for the prevention and treatment of estrogen receptor-positive (ER+) breast cancer and other hormone-sensitive conditions. It acts as an estrogen antagonist in breast tissue while potentially maintaining beneficial estrogenic effects in bone and other tissues. Acolbifene binds to estrogen receptors, blocking estrogen-driven cell proliferation without triggering full receptor activation. The hydrochloride salt enhances its solubility and formulation stability. Investigational studies suggest acolbifene may offer a favorable safety profile compared to traditional SERMs, with reduced risk of endometrial stimulation and thromboembolic events.
| CAS Number | 252555-01-4 |
| Synonyms | (2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2H-chromen-7-ol;hydrochloride |
| Molecular Formula | C29H32ClNO4 |
| Purity | ≥95% |
| IUPAC Name | (2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2H-chromen-7-ol;hydrochloride |
| InChI | InChI=1S/C29H31NO4.ClH/c1-20-26-14-11-24(32)19-27(26)34-29(28(20)21-5-9-23(31)10-6-21)22-7-12-25(13-8-22)33-18-17-30-15-3-2-4-16-30;/h5-14,19,29,31-32H,2-4,15-18H2,1H3;1H/t29-;/m0./s1 |
| InChIKey | BYQDPIXWTVEVEA-JMAPEOGHSA-N |
| SMILES | CC1=C([C@@H](OC2=C1C=CC(=C2)O)C3=CC=C(C=C3)OCCN4CCCCC4)C5=CC=C(C=C5)O.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
