For research use only. Not for therapeutic Use.
Aclimostat (Cat No.: I021302) is a potent inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme that regulates fatty acid synthesis and oxidation. By blocking ACC activity, Aclimostat reduces hepatic lipogenesis and enhances fatty acid oxidation, leading to improved lipid metabolism. It has been investigated as a therapeutic candidate for nonalcoholic steatohepatitis (NASH), obesity, and metabolic disorders. In research, Aclimostat serves as a valuable tool for studying lipid metabolism, energy balance, and the therapeutic potential of ACC inhibition.
| CAS Number | 2082752-83-6 |
| Synonyms | [(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl] 3-(2-morpholin-4-ylethyl)azetidine-1-carboxylate |
| Molecular Formula | C26H42N2O6 |
| Purity | ≥95% |
| InChI | InChI=1S/C26H42N2O6/c1-18(2)5-6-21-25(3,34-21)23-22(30-4)20(7-9-26(23)17-32-26)33-24(29)28-15-19(16-28)8-10-27-11-13-31-14-12-27/h5,19-23H,6-17H2,1-4H3/t20-,21-,22-,23-,25+,26+/m1/s1 |
| InChIKey | QJWJPMLDQYEPPW-AUKZVGPFSA-N |
| SMILES | CC(=CCC1C(O1)(C)C2C(C(CCC23CO3)OC(=O)N4CC(C4)CCN5CCOCC5)OC)C |
| Reference | [1]. Burkey BF, Hoglen NC, Inskeep P, Wyman M, Hughes TE, Vath JE. Preclinical Efficacy and Safety of the Novel Antidiabetic, Antiobesity MetAP2 Inhibitor ZGN-1061. J Pharmacol Exp Ther. 2018 May;365(2):301-313. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
