Acid-C2-PEG4-C2-NHS ester

• CAT Number: I016366
• CAS Number: 1343476-41-4
• Molecular Formula: C18H29NO11
• Molecular Weight: 435.42
• Purity: ≥95%
• Synonyms: 3-[2-[2-[2-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C18H29NO11/c20-15-1-2-16(21)19(15)30-18(24)4-6-26-8-10-28-12-14-29-13-11-27-9-7-25-5-3-17(22)23/h1-14H2,(H,22,23)
• InChIKey: QMACGMMKGUAJOY-UHFFFAOYSA-N
• SMILES: C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCC(=O)O

Acid-C2-PEG4-C2-NHS ester(CAT: I016366) is a heterobifunctional PEG linker designed for efficient bioconjugation. It features a terminal carboxylic acid on one end and an N-hydroxysuccinimide (NHS) ester on the other, separated by a four-unit polyethylene glycol (PEG4) spacer with C2 linkers. The PEG4 chain enhances solubility, reduces steric hindrance, and provides flexibility for molecular interactions. The NHS ester reacts readily with primary amines to form stable amide bonds, while the free acid allows further derivatization or coupling. This reagent is widely used in antibody–drug conjugates, peptide modifications, and surface functionalization, enabling precise and efficient biomolecule crosslinking strategies.