ACG416B

• CAT Number: I045518
• CAS Number: 795316-15-3
• Molecular Formula: C38H36Br2N4
• Molecular Weight: 708.53
• Purity: ≥95%
• Synonyms: N-methyl-1-[[3-[3-[[4-(N-methylanilino)pyridin-1-ium-1-yl]methyl]phenyl]phenyl]methyl]-N-phenylpyridin-1-ium-4-amine;dibromide
• InChI: InChI=1S/C38H36N4.2BrH/c1-39(35-15-5-3-6-16-35)37-19-23-41(24-20-37)29-31-11-9-13-33(27-31)34-14-10-12-32(28-34)30-42-25-21-38(22-26-42)40(2)36-17-7-4-8-18-36;;/h3-28H,29-30H2,1-2H3;2*1H/q+2;;/p-2
• InChIKey: NOXDPLVCKHQSFW-UHFFFAOYSA-L
• SMILES: CN(C1=CC=CC=C1)C2=CC=[N+](C=C2)CC3=CC(=CC=C3)C4=CC=CC(=C4)C[N+]5=CC=C(C=C5)N(C)C6=CC=CC=C6.[Br-].[Br-]

ACG416B (Cat No.: I045518) is a selective small-molecule inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), a heme-containing enzyme that catalyzes the degradation of tryptophan into kynurenine. By blocking IDO1 activity, ACG416B modulates immune tolerance and enhances antitumor immune responses. Researchers employ this compound to study tumor immunology, T-cell regulation, and mechanisms of immune escape in cancer. Its activity provides a valuable tool for exploring immunometabolism and evaluating therapeutic strategies that combine IDO1 inhibition with checkpoint blockade in oncology and inflammation research.

Reference

[1]. onejo-García A, et al. Influence of the linker in bispyridium compounds on the inhibition of human choline kinase. J Med Chem. 2004 Oct 21;47(22):5433-40.
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