Ac2-26 ammonium

• CAT Number: I040249
• Molecular Formula: C141H210N32O44S.xNH3
• Molecular Weight: 3089.43 (free base)
• Purity: ≥95%

Ac2-26 ammonium(CAT: I040249) is a bioactive N-terminal peptide fragment of annexin 1, known for its potent anti-inflammatory properties. It acts through chaperone-mediated autophagy (CMA) to reduce lysosomal IKKβ protein levels, thereby modulating NF-κB signaling. Ac2-26 has demonstrated therapeutic potential in various inflammatory conditions, including lung ischemia-reperfusion injury, where it significantly ameliorates tissue damage. In asthma models, Ac2-26 ammonium effectively reduces airway inflammation and hyperresponsiveness, highlighting its utility in respiratory and immune-mediated disease research. This peptide is a valuable tool for exploring inflammation resolution mechanisms, autophagy regulation, and annexin A1 signaling pathways in preclinical models.