Ac-pSar12-OH

• CAT Number: I040421
• CAS Number: 2313534-24-4
• Molecular Formula: C38H64N12O14
• Molecular Weight: 912.99
• Purity: ≥95%
• Synonyms: 2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[acetyl(methyl)amino]acetyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetic acid
• InChI: InChI=1S/C38H64N12O14/c1-26(51)39(2)14-27(52)40(3)15-28(53)41(4)16-29(54)42(5)17-30(55)43(6)18-31(56)44(7)19-32(57)45(8)20-33(58)46(9)21-34(59)47(10)22-35(60)48(11)23-36(61)49(12)24-37(62)50(13)25-38(63)64/h14-25H2,1-13H3,(H,63,64)
• InChIKey: IOFCDTUBHNNIHO-UHFFFAOYSA-N
• SMILES: CC(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)O

Ac-pSar12-OH(CAT: I040421) is a polyethylene glycol-like polypeptoid linker composed of 12 sarcosine (N-methylglycine) units, capped with an N-terminal acetyl group and a free carboxyl group at the C-terminus. It is specifically designed for use in the synthesis of Ligand-Drug Conjugates (LDCs), where it serves as a flexible, hydrophilic spacer that enhances solubility, stability, and pharmacokinetics. Ac-pSar12-OH minimizes immunogenicity and reduces steric hindrance, allowing optimal positioning of payloads relative to targeting ligands. This linker is ideal for precision conjugation strategies in targeted drug delivery systems, particularly for therapeutic applications in oncology and receptor-specific cellular targeting research.