Ac-Lys-AMC

• CAT Number: M104492
• CAS Number: 156661-42-6
• Molecular Formula: C18H23N3O4
• Molecular Weight: 345.39
• Purity: ≥95%
• Synonyms: (2S)-2-acetamido-6-amino-N-(4-methyl-2-oxochromen-7-yl)hexanamide
• InChI: InChI=1S/C18H23N3O4/c1-11-9-17(23)25-16-10-13(6-7-14(11)16)21-18(24)15(20-12(2)22)5-3-4-8-19/h6-7,9-10,15H,3-5,8,19H2,1-2H3,(H,20,22)(H,21,24)/t15-/m0/s1
• InChIKey: NBOQAQRQQNJREL-HNNXBMFYSA-N
• SMILES: CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)[C@H](CCCCN)NC(=O)C

Ac-Lys-AMC (Cat No.:M104492) is a fluorogenic substrate commonly used to study lysine deacetylase and protease activity. Upon enzymatic cleavage, it releases 7-amino-4-methylcoumarin (AMC), a fluorescent moiety that can be quantitatively measured, enabling sensitive detection of enzymatic kinetics. This compound is valuable in high-throughput screening, inhibitor characterization, and mechanistic studies of deacetylases and proteases. Its acetylated lysine residue mimics natural substrates, providing physiological relevance. Ac-Lys-AMC is widely employed in epigenetics and enzymology research to explore post-translational modifications and enzyme regulation in cellular processes.