For research use only. Not for therapeutic Use.
Ac-Exatecan(CAT: I040438) is an acetylated derivative of Exatecan (DX-8951, HY-13631), a potent topoisomerase I inhibitor widely utilized as a cytotoxic payload in antibody-drug conjugates (ADCs). By interfering with DNA replication and transcription, Ac-Exatecan exerts strong antiproliferative effects, making it suitable for targeted cancer therapy development. The acetyl modification may enhance solubility, stability, or facilitate linker attachment in ADC synthesis workflows. With an IC₅₀ of 2.2 μM against topoisomerase I, it retains the core cytotoxic activity of Exatecan. Ac-Exatecan is ideal for ADC payload engineering, mechanism-of-action studies, and the creation of next-generation conjugates for precision oncology applications.
| CAS Number | 2922852-48-8 |
| Synonyms | N-[(10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl]acetamide |
| Molecular Formula | C26H24FN3O5 |
| Purity | ≥95% |
| IUPAC Name | N-[(10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl]acetamide |
| InChI | InChI=1S/C26H24FN3O5/c1-4-26(34)16-7-20-23-14(9-30(20)24(32)15(16)10-35-25(26)33)22-18(28-12(3)31)6-5-13-11(2)17(27)8-19(29-23)21(13)22/h7-8,18,34H,4-6,9-10H2,1-3H3,(H,28,31)/t18-,26-/m0/s1 |
| InChIKey | SRCUCWPOTBGIQM-QYBDOPJKSA-N |
| SMILES | CCC1(C2=C(COC1=O)C(=O)N3CC4=C5C(CCC6=C5C(=CC(=C6C)F)N=C4C3=C2)NC(=O)C)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
